INS and obesity disorder: For instance, chronic low-level inflammation in viral hepatitis (a disease of the liver causing inflammation), obesity, or alcohol abuse is a risk factor for liver cancer [11]; increased levels of insulin and insulin-like growth factor-1 (IGF-1) may promote the development of colon, kidney, prostate, and endometrial cancers [12]; high levels of estrogen have been associated with increased risk of endometrial, breast, and ovarian cancer [13–15]; and circadian deregulation in night shift workers or in obesity has been connected with increased risk of breast cancer [10].