Prostate-specific membrane antigen (PSMA), also known as folate hydrolase I or glutamate carboxypeptidase II, is overexpressed by tumor cells or neovascular endothelial cells, such as prostate cancer (PCa), ACC, renal cell carcinoma, and hepatocellular carcinoma [13–19]. Here, FOLH1 is linked to hereditary clear cell renal cell carcinoma.