Prostate-specific membrane antigen (PSMA), also known as folate hydrolase I or glutamate carboxypeptidase II, is overexpressed by tumor cells or neovascular endothelial cells, such as prostate cancer (PCa), ACC, renal cell carcinoma, and hepatocellular carcinoma [13–19]. The gene discussed is FOLH1; the disease is Familial prostate cancer.