In our cohort, the single-cell data suggest, in this small series, that TRAF7 mutation is typically acquired first, but in line with bulk data also supports that the co-mutation of TRAF7 is still either not indispensably needed in every KLF4 or AKT1 mutant meningioma, or that some TRAF7-modifying events are not captured with the current approaches. The gene discussed is TRAF7; the disease is meningioma.