The analyses here were initiated after diagnostic work-up of the tumors of a 47-year-old male patient with two independent meningiomas having identical somatic TRAF7 mutation N520S, but separate AKT1 (skull base, meningothelial) and KLF4 (convexity, secretory type) hotspot mutation (Fig. 1a). This evidence concerns the gene AKT1 and meningioma.