TP53 and lung carcinoma: Once again, circ-ZKSCAN1 can inhibit the transcriptional actions of the Wnt/β-catenin signaling pathway by blocking another target, fragile X mental retardation protein (FMRP), suppressing the process of stemness.[94] Furthermore, hsa_circ_100395 can act as an miRNA sponge to inhibit miR-1228, which acts as an oncogene in lung cancer, and represses p53 expression to inhibit apoptosis.[95,96] We can infer that different circRNAs, or even for the same circRNA, their promotive or inhibitory effects on cancer are influenced by their targets and cell-specificity.