CDH1 and lung cancer: Notably, its expression is known to be a predictive marker for lung cancer, particularly metastasis.[60] When MALAT1 is knocked down in A549 cells, dysregulation of metastasis-associated transcripts and growth control genes can be observed in lung cancer cells.[61] In addition, silencing MALAT1 restored the expression level of E-cadherin and inhibited the EMT process, thereby reducing brain metastases in patients with lung cancer.[62] While similar results were not observed in HeLa cells, implying that the role of MALAT1 may be cell type-specific.[61]