A lncRNA-NKILA/NF-κB feedback loop exists in which NKILA can firmly combine with the NF-κB: IκB complex to inhibit the phosphorylation of IκB, leading to NF-κB inactivation and inflammation suppression, whereas NF-κB can bind to the NKILA promoter region and initiate its transcription.[78,79] Herein, Wu et al also confirmed that TGF-β upregulated NKILA expression in an NF-κB-dependent manner, which in turn regulated NF-κB activity and EMT in breast cancer. This evidence concerns the gene NFKB1 and breast carcinoma.