Under the involvement of enhancer of zeste homolog 2 (EZH2), HOTAIR suppressed death receptor 5 (DR5) expression, which is a TRAIL receptor, resulting in resistance to TRAIL-induced apoptosis in pancreatic cancer.[56] Overexpression of HOTAIR is accompanied by overexpression of hexokinase-2 (HK2), resulting in accelerated energy metabolism in pancreatic adenocarcinoma cells.[57]. Here, HK2 is linked to familial pancreatic carcinoma.