HMGB1 and Familial prostate cancer: By sponging miR-129-5p, MALAT1 enhances colon tumorigenesis and increases the expression of high mobility group box protein 1 (HMGB1), a target of miR-129-5p that ordinarily protects cells from injury.[65] Analogous findings exist in the MALAT1/miR-429 axis in cervical cancer,[66] MALAT1/miR-204/IGF2BP2/m6A-MYC axis in thyroid cancer,[67] MALAT1/miR-23b-3p/ATG12 axis in gastric cancer (GC),[68] and MALAT1/miR-140/BIRC6 axis in prostate cancer.[69] Fortunately, knockdown and silencing can reverse the effects of MALAT1, inhibit the growth and metastasis of tumor cells, and promote apoptosis.