E2F7 and cancer: E2F7 is a priming factor involved in cell cycle regulation, apoptosis and differentiation, involved in the late stage of mitosis, embryonic development, DNA stress response, and is likely to participate in the occurrence of tumors.[6–9] As an epithelial transcription inhibitor, amplification, overexpression or deletion of E2F7 can be observed in many malignant tumors, and it can affect tumor differentiation, proliferation and metastasis by interacting with different downstream targets.