E2F7 and neoplasm: E2F7 is different from the typical E2Fs members in that it binds to DNA in a non-DP protein way to play a transcriptional inhibitory effect.[4,39] Studies have shown that E2F7 can inhibit cell proliferation by inhibiting the transcription of proliferation-related miRNAs.[40] However, in recent years, more and more studies have shown that E2F7 plays a role in promoting tumor occurrence and development in tumors.