CD274 and lung adenocarcinoma: Previous studies have shown that PD-L1 TPS ≥50% rarely overlaps with the presence of EGFR, ALK, ROS1, and other driving oncogenes.[1] However, Ma et al[15] showed that the expression of PD-L1 protein in a human lung adenocarcinoma cell line with EML4-ALK fusion gene was higher than that in an identical cell line without the fusion gene.