To assess the impact on tumor initiation we deleted EHMT2 using a conditional allele of the Ehmt2 gene (Ehmt2 fl/fl) together with conditional KrasG12D in the absence or presence of Trp53 loss (KPE: Kraslsl.G12D/wt: Trp53fl/fl; Ehmt2fl/fl and KE: Kraslsl.G12D/wt; Ehmt2fl/fl) KPE mice showed a striking reduction in tumor formation and significant decrease in tumor burden in comparison to KP mice, which translated to a significant increase in overall survival (Figure 6—figure supplement 7A,B). The gene discussed is EHMT2; the disease is neoplasm.