It resulted in lower serum levels of organ dysfunction markers and also IFN-γ in Dnajb4−/− mice comparing with wild-type mice (Figures 1C, D, 2C), suggesting the effect of HLJ1 deletion on reducing IFN-γ levels and alleviating organ injury can be found as well during moderate endotoxemia. Here, DNAJB4 is linked to serum lipopolysaccharide activity.