Within efforts to develop degraders for the androgen receptor (AR) in metastatic castration-resistant prostate cancer, and to improve their cellular potency compared to previously reported AR degraders, such as ARCC-4 (Table 1),120 the Wong group identified the methylated benzylic position at the RHS of VHL inhibitors as attractive tethering point for linker attachment.94 This evidence concerns the gene VHL and prostate cancer.