Using this strategy, the Deiters laboratory developed photocleavable ERRα degraders using diethylamino coumarin (DEACM) as caging group attached to the Hyp hydroxyl via carbonate linkage.191 While the caged degrader 104 was completely inactive, photolysis with <405 nm light released the corresponding active degrader within 3 min (Fig. 45a), which induced significant reduction in ERRα levels in cancer cells. This evidence concerns the gene ESRRA and cancer.