A follow-up study on related AR degraders focused on the influence of the binary binding affinity of the VHL-recruiting moiety towards VHL on degrader efficacy.172 For this purpose, the 4-methylthiazole unit from ARD-61 was replaced with smaller functionalities and the corresponding PROTACs were evaluated for their ability to reduce AR protein levels in prostate cancer cells.172 Effective reduction of AR protein levels was observed with all first series PROTACs, despite considerable differences in their binding affinity to VHL. The gene discussed is VHL; the disease is Familial prostate cancer.