ARV-771 qualified as a potent degrader of Brd2, Brd3 and Brd4 with DC50 values <5 nM in 22Rv1 cancer cells and led to decreases in tumour size in xenograft models in mice.93 Together with MZ1, ARV-771 has been widely used as a benchmark PROTAC degrader of BET proteins (see below, Sections 4.6 and 4.7). This evidence concerns the gene BRD4 and neoplasm.