FAK has multiple roles acting as regulator of intracellular signal transduction, driver of cancer cell growth and acting as kinase-independent scaffold for various signalling proteins.147 As high FAK protein levels have been detected in several solid tumour types,148 FAK has been addressed as a therapeutic target with inhibitors149,150 and both VHL- and CRBN-recruiting PROTACs.117,118,151,152. The gene discussed is VHL; the disease is cancer.