However, considering the critical involvement of CHAC1 in glioma apoptotic cell death, the suppression of neuroblastoma cell proliferation and mediating antitumour activity of artesunate, nisin, and temozolomide highlights the opposite regulatory function of CHAC1 in cell proliferation and migration of different tumour tissues [39, 47, 48]. This evidence concerns the gene CHAC1 and neuroblastoma.