Here we report on a man with very severe asthma who has (i) a typical allergic background: allergic rhinitis to pollen, animal hair, and house dust mites since childhood, (ii) high IgE, (iii) specific IgE antibodies against seasonal and perennial allergens, (iv) non-allergic mechanisms, and (v) aspirin-exacerbated respiratory disease (AERD). Here, IGHE is linked to respiratory system disorder.