SNAI1 and adrenal cortex carcinoma: The relevant research results show that more than 95% of the clinical stage III and IV adrenocortical carcinoma tumors have positive Snail expression [24]; ER-negative expression adrenal cortical carcinoma patients have a lower 5-year survival rate than those with ER-positive expression and have a greater chance of distant metastasis [25, 26].