(3) Sepsis releases a large amount of catecholamine, stimulates cardiomyocyte β-receptor, and increases heart rate, and persistent tachycardia will cause cardiomyocyte calcium overload and myocardial necrosis, a large amount of cTnI is released into the blood, and the level of cTnI will increase with the severity of sepsis. Here, TNNI3 is linked to Sepsis.