There was no significant difference in the percentage of overweight or obesity, serum levels of FBG, insulin, HOMA-IR, HOMA-β, TG, TC, LDL-C, HDL-C, OC, ucOC and ucOC/OC among the four subgroups of genotypes (Supplementary Table 1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.