SFTPB and newborn respiratory distress syndrome: Disease due to SFTPB variants typically presents in neonates as respiratory distress syndrome, resulting in death within the first few months; variants that allow partial production of the SP-B protein confer longer survival times and later onset of disease, whereas the variants that cause complete deficiency of SP-B due to NMD cause fatal neonatal respiratory distress syndrome (van Moorsel et al., 2021).