Although anaemia in IBD is mostly combined effect of IDA and anaemia of chronic disease (ACD), IDA alone remains a significant factor through reduced intake of iron owing to exclusion of food products which can aggravate symptoms of IBD; GI bleed (chronic); impaired iron absorption in Crohn's disease of the duodenum or upper jejunum; and an enhanced response of erythropoietin which is not paired with the accessible iron, leading to a non-effective erythropoietic process [8-10]. This evidence concerns the gene EPO and anemia.