For example, some genes have been identified as preferentially mutated in breast cancer metastases, when collectively considering all the studies: TP53[9]; ESR1 [5], [10], [11]; ERBB2 [12]; JAK2 [13]; NF1 [5], [12]; PALB2 [11], [14]; STAT3[13] TSC1/2 [14]; KMT2D, KTM2C [6], [7] and also ERBB3, FBXW7, GATA1, KRAS, MEN1, NF1 [5]. This evidence concerns the gene ESR1 and breast carcinoma.