The oncogenic long non-coding RNA (lncRNA) HOTAIR induces altered histone H3 lysine 27 methylation and thus has been shown to promote the enrichment of the TNFα/NF-κB signaling protein complex, the IκB kinase complex, and the IKK1-IKK2 complex in glioma cells (Wang et al., 2021). The gene discussed is NFKB1; the disease is central nervous system cancer.