Three isoforms of BIN1 were detected in neurons and astrocytes (isoforms 1, 2, and 3) and four isoforms in microglia (isoforms 6, 9, 10, and 12) of human brain (Taga et al., 2020) showing a strong association of BIN1 isoforms expressed by neurons/astrocytes and tangles that might contribute to cognitive decline in AD. This evidence concerns the gene BIN1 and Mental deterioration.