Our own review (Kaltschmidt B. et al., 1993) on this topic suggested an involvement of NF-κB based on the production of reactive oxygen intermediates in various neurological diseases, such as multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and others. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.