CASP3 and Sepsis: Accordingly, the kidney injury (mainly determined through renal tubular damage such as vacuolization, swelling, and desquamation) and liver damage (mainly evaluated by cell vacuolization) in CLP with sepsis feces were higher than in CLP with sham feces, while cell apoptosis (brown color stained in activated caspase 3 staining) in the spleen was not different between these groups (Figures 4A–D).