Many studies had shown that the IgE titer of recombinant A.f in ABPA patients was higher than that in non-ABPA asthma, which indicated that ABPA patients had a stronger T2 immune response to A.f and produce a high level of sIgE and tIgE (23, 24). This evidence concerns the gene IGHE and allergic bronchopulmonary aspergillosis.