The result identified that the frequency of metaclusters of pop 10 (CD3+CD4+PD-1+CD127+IFN-γ+), pop 13 (CD3+CD4+PD-1+IFN-γ+) and pop 6 (CD3+CD4+CD127+CXCR5+) were higher in the ABPA group compared with that in the A.f (+)-asthma group; meanwhile, pop 13 (CD3+CD4+ PD-1+IFN-γ+) increased and pop 11 (CD3+CD4+CD25+CD127+PD-1+) decreased after exposure to allergen in the ABPA patients. The gene discussed is CD4; the disease is allergic bronchopulmonary aspergillosis.