In our study, we that found Asp f9-sIgA and Asp f9-sIgE and Asp f3-sIgE in the ABPA group was significantly higher than those in A.f-sensitized asthma, however, specific antibodies (including IgG4, IgE, and IgA) against Asp f1 showed no difference in the two groups. The gene discussed is IGHE; the disease is allergic bronchopulmonary aspergillosis.