In our study, we found that the IFN-γ+Th1 cells especially CD3+CD4+PD-1+CD127+IFN-γ+T cells significantly increased in ABPA patients when compared to A.f-sensitized patients, which suggested that there might be more severe airway epithelial damage in the ABPA patients, driving a shift to Th1 inflammation. The gene discussed is CD4; the disease is allergic bronchopulmonary aspergillosis.