Documented cardiac manifestations in IIM patients are diverse including myocardial ischemia, arrhythmias, conduction defects, cardiomyopathies, pericardium diseases, and pulmonary hypertension (5), whereas reports of cardiac involvement in anti-MDA5 Ab+ dermatomyositis/clinically amyopathic dermatomyositis (DM/CADM) patients are scarce. Here, IFIH1 is linked to clinically amyopathic dermatomyositis.