Documented cardiac manifestations in IIM patients are diverse including myocardial ischemia, arrhythmias, conduction defects, cardiomyopathies, pericardium diseases, and pulmonary hypertension (5), whereas reports of cardiac involvement in anti-MDA5 Ab+ dermatomyositis/clinically amyopathic dermatomyositis (DM/CADM) patients are scarce. The gene discussed is IFIH1; the disease is acquired idiopathic inflammatory myopathy.