Interestingly, some fetuses exposed to recoded Zika virus E+102CpG and particularly E/NS1+176CpG variant showed a trend to higher IFN-γ levels—cytokine critical for immunity against virus infections and eliciting vaccine responses—in comparison to fetuses exposed to the wild-type variant (Figures 6C, D); however, a statistically significant difference was not observed (amniotic fluid: p > 0.99; blood plasma: p > 0.99). This evidence concerns the gene IFNG and viral infectious disease.