In certain strains with aggressive lupus (i.e. NZM2410, NZBWF1, and New Zealand Black, or NZB, lupus mice), cSiO2 exposure increases ANA, anti-histone, anti-dsDNA, anti-ssDNA, and/or anti-RNP, Sm, Ro/SSA, and La/SSB Ig (19–28). The gene discussed is SSB; the disease is systemic lupus erythematosus.