The higher the stage of colon cancer, the lower the expression of B2M mRNA (normal-vs-stage1: p=2.42909999892404E − 08; normal-vs-stage2: p=2.26879626197274E − 11; normal-vs-stage3: p=3.46889961200247E − 10; normal-vs-stage4: p=8.27404811332144E − 12; stage1-vs-stage4: p=1.609760E − 02; stage2-vs-stage4: p=3.202300E − 03) (Figure 4). Here, B2M is linked to malignant colon neoplasm.