TCGA database analysis showed that B2M mRNA expression was not associated with lymph node metastasis (normal-vs-N0: p=1.79600001537494E − 09; normal-vs-N1: p=2.08109973698356E − 10; normal-vs-N2: p=1.10179976253733E − 10) (Figure 6). The gene discussed is B2M; the disease is metastatic malignant neoplasm in the lymph nodes.