The results of TCGA database analysis showed that the expression level of B2M mRNA in colon adenocarcinoma tissues was correlated with the TP53 mutation status, and the expression level of B2M mRNA in TP53 mutated colon cancer tissues was lower than that in nonmutated colon adenocarcinoma tissues (normal-vs-tp53-mutant: p=5.69789770921147E − 11; normal-vs-tp53-nonmutant: p=6.83500001041892E − 09; tp53-mutant-vs-tp53-nonmutant: p=8.608400E − 04) (Figure 7). The gene discussed is TP53; the disease is colon adenocarcinoma.