To identify alterations that occur in pancreatic cancer cells able to survive LDHA inhibition, we treated the oxamate-sensitive glycolytic PDAC cell line MIAPaCa2 (parental cells) with 10 mM oxamate for 4 weeks to generate an oxamate-resistant PDAC cell line (Figure 1A). This evidence concerns the gene LDHA and familial pancreatic carcinoma.