HIF1A and neoplasm: Furthermore, we also investigated Vascular endothelial growth factor receptor 2 (VEGFR2) and Hypoxia-inducible factor 1-alpha (HIF1α) protein expression that activates genes involved in migration, angiogenesis, and survival, such as VEGFs that are found to be overexpressed in tumor cells, suggesting that these proteins also have involvement in tumor progression (38).