GSTM1 and neoplasm: Matrigel plugs of animals dosed with NPC-402 (10 mg/kg/body weight) and dacarbazine (60 mg/kg/body weight) show significant alleviation in vascularization, tumor volume, and weight and appear white with negligible Hb content (Figures 5A, B), indicating that NPC-402 significantly inhibited angiogenesis.