In conclusion, our data present, for the first time, preliminary evidence that JAK1 (c.1648+1272G>A, c.991-27C>T), JAK2 (c.-1132G>T), and STAT3 (c.*1671T>C, c.-1937C>G) SNVs alter the risk and clinical aspect of CM patients, where STAT3c.-1937C>G JAK1 c.991-27C>T has the most important action. Here, STAT3 is linked to cutaneous mastocytosis.