Our group investigated, in the current study, whether JAK1 (c.1648+1272G>A, c.991-27C>T), JAK2 (c.-1132G>T, c.-139G>A), and STAT3 (c.*1671T>C, c.-1937C>G) SNVs alter the risk, clinicopathological aspects, and prognosis of CM as well as the activity of respective proteins. Here, STAT3 is linked to cutaneous mastocytosis.