Instead, the LIAS expression was downregulated in most cancers, like breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), KIRC, kidney renal papillary cell carcinoma (KIRP), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC) (Figure 1A). Here, LIAS is linked to colon adenocarcinoma.