WNT3A and neoplasm: Further, blocking IL17A, PN or WNT3A only reduced tumor sphere formation in CICs isolated from resistant cells, while having no effect in CICs derived from sensitive cells (Supplementary Figure 1C) indicating that PN, WNT3A and IL17A induced tumorigenic activity is confined to the role of increased CAFs after FOLFOX treatment (as seen in Figure 1D).