Given that CAFs derived from resistant tumor cells (PD-5FUR, PD-OXAR and PD-FR CAFs) also express significant levels of CD44v6 compared to its absence in normal-fibroblasts (as seen in Figure 4B), we determined if CD44v6 induces WNT3A activation in CAFs since it regulates WNT3A/β-catenin signaling in CICs (48). This evidence concerns the gene WNT3A and neoplasm.