Other studies demonstrated that another component of the tRNA m7G methyltransferase complex, methyltransferase-like 1 (METTL1), was upregulated in some malignancies, such as hepatocellular carcinoma and lung adenocarcinoma, and was associated with poor patient prognosis and resistance to chemotherapy (22, 23). This evidence concerns the gene METTL1 and lung adenocarcinoma.