As shown in Figure 5A, with the exception of four tumors (ACC, GBM, Pheochromocytoma and Paraganglioma (PCPG), and Cholangiocarcinoma (CHOL)), there was an evident negative correlation between the PXDN expression and the methylation level in all other tumors. The gene discussed is PXDN; the disease is pheochromocytoma-paraganglioma.