CCL5 and neoplasm: Although there is a high tumor heterogeneity for TAMs within ccRCC, we found that increased abundance of tumor-infiltrating CCL5+ TAMs represented worse OS and PFS compared to tumors with lower CCL5+ TAMs-infiltration in ccRCC patients (OS, P<0.0001, HR=1.923; PFS, P=0.0003, HR=1.807; Figure 7D-E).