The Cibersort algorithm was used in 530 ccRCC samples from TCGA and compared the differential levels of immune checkpoints activation (CD160, CD69, TNF, IFNG, PRF1, and GZMB) and exhaustion (PDCD1, KLRG1, LAG3, TIGIT, HAVCR2, CTLA4, CD28, CD96, PD-L1, PD-L2, and SIGLEC10) signatures. Here, LAG3 is linked to nonpapillary renal cell carcinoma.