We speculated that by activating the PI3K/AKT pathway, CCL5 increased Snail1 expression, which led to the downregulation of the epithelial marker E-cadherin and upregulation of the mesenchymal markers Vimentin and Fibronectin, thus promoting the EMT, migration, and metastasis of ccRCC cells. Here, CCL5 is linked to nonpapillary renal cell carcinoma.