STAT3 and Familial prostate cancer: Furthermore, In the TIME, TAMs-secreted CCL5 could prominently facilitates the migration, invasion, and epithelial-mesenchymal transition (EMT) of prostate cancer cells via activation of β-catenin/STAT3 signaling 17, and promotes immune evasion of colorectal cancer cells through the p65/STAT3-CSN5-PD-L1 pathway 18.