The Cibersort algorithm was used in 530 ccRCC samples from TCGA and compared the differential levels of immune checkpoints activation (CD160, CD69, TNF, IFNG, PRF1, and GZMB) and exhaustion (PDCD1, KLRG1, LAG3, TIGIT, HAVCR2, CTLA4, CD28, CD96, PD-L1, PD-L2, and SIGLEC10) signatures. This evidence concerns the gene PDCD1LG2 and nonpapillary renal cell carcinoma.