SH3BP1 belongs to the Rho GTPase activating protein family and mediates cell motility 72, in a similar manner to that observed during EMT in prostate cancer, hepatocellular carcinoma (HCC) and cervical cancer via the Rac family small GTPase 1-WASP family member 2 pathway 73-75. This evidence concerns the gene SH3BP1 and Familial prostate cancer.