Furthermore, using the TIDE database (http://tide.dfci.harvard.edu), we calculated the correlations of CPNE8 with dysfunction and TIDE scores and found that increased CPNE8 expression was associated with higher immune dysfunction (R =0.19, p =0.00025) (Figure 7D) and TIDE scores (R =0.19, p =0.00025) (Figure 7E). This evidence concerns the gene CPNE8 and immune system disorder.