UCP1 and obesity due to melanocortin 4 receptor deficiency: Conversely, the specific deletion of METTL3 in the BAT reduces the expression of Prdm16 and UCP1 transcripts, which impairs BAT maturation, thus resulting in a marked reduction in BAT-mediated adaptive thermogenesis and high-fat diet (HFD)-induced obesity and systemic insulin resistance 44.