Our results present here indicate that KLF4 positively regulates Rictor-mediated epithelial-mesenchymal transition as well as tumor metastasis of NSCLC in vivo and may function as a tumor-promoting gene, which is partially consistent with those of Fadous-Khalifé et al. 70, Feng et al. 68 and Naranjo Gómez et al. 69 but not consistent with those of Hu et al. 67. Here, RICTOR is linked to neoplasm.