Knockdown of Rictor impairs TGFβ-induced downregulation of E-cadherin protein, compromises TGFβ-induced increase in N-cadherin and Snail expression in NMuMG cells, blocks TGFβ-induced EMT and invasive behavior of both NMuMG cells and E4 squamous carcinoma cells. The gene discussed is CDH2; the disease is squamous cell carcinoma.