Our results present here indicate that KLF4 positively regulates Rictor-mediated epithelial-mesenchymal transition as well as tumor metastasis of NSCLC in vivo and may function as a tumor-promoting gene, which is partially consistent with those of Fadous-Khalifé et al. 70, Feng et al. 68 and Naranjo Gómez et al. 69 but not consistent with those of Hu et al. 67. This evidence concerns the gene KLF4 and non-small cell lung carcinoma.