When the above BMDM was co-cultured with mouse primary spleen CD3 + T lymphocytes, it was also found that the ability of promoting apoptosis of T lymphocytes by BMDM induced by hepatoma cells was weakened after the silencing of ALKBH5 (Fig. 7b, S7a and S7b). This evidence concerns the gene ALKBH5 and hepatocellular carcinoma.