IL18 and acute kidney injury: Further ELISA showed significant upregulation of renal IL-1β and IL-18 in Atg7ΔTE mice with LIE in comparison to those in Atg7flox/flox mice with LIE after high-dose ascorbate therapy (Figure 3D), proposing that tubular mitophagy is involved in the high-dose ascorbate-boosted M2 macrophages for the anti-inflammatory immune responses during septic AKI.