NFE2L2 and acute kidney injury: In proof-of-principle studies, we establish that the tubular mitophagy-dependent SerpinG1 secretion mediated by NRF2 transactivation contributes to the anti-inflammatory macrophage polarization and anti-septic AKI effects of high-dose ascorbate therapy (Figure 7G), suggesting that renal SerpinG1 might serve as a biomarker to predict responsiveness of high-dose ascorbate therapy.