Importantly, several circRNAs were reported to modulate GBM tumorigenesis and progression; for example, circTTBK2 promotes glioma malignancy by regulating the miR-217/HNF1β/Derlin-1 pathway, while circFBXW7 inhibits GBM tumorigenesis by encoding a protein named FBXW7-185aa. The gene discussed is DERL1; the disease is glioblastoma.