Additionally, Gong et al. [33] reported that CSCs signaling pathways simultaneously occur with an intrinsic activation of Interferon alpha and beta receptor subunit 1(IFNAR1) signaling, affecting the anti-tumor stimulation function of stimulator of interferon response cGAMP interactor 1 (STING1) on CD8+ lymphocytes by induction of a hypo-responsiveness status in HNSCC. This evidence concerns the gene STING1 and head and neck squamous cell carcinoma.