Using Next-Generation Sequencing (NGS) techniques to better characterize this mechanism, the results showed that CD276 is crucial for CSCs immune evasion, and blockade with anti-CD276 eliminates these cells in a CD8+ T cell-dependent manner, in addition to remodeling HNSCC heterogeneity and decreasing EMT [23]. The gene discussed is CD276; the disease is head and neck squamous cell carcinoma.