Adiponectin-regulation and signalling have been widely studied in multisystem inflammatory illnesses and shown to be negatively associated with obesity and diabetes, both well-established comorbidities in PTSD (Farr et al., 2014; Koenen et al., 2017; Rao et al., 2014). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.