With a threshold of p less than 0.01 and a correlation coefficient over 0.60, ARHGAP29, C4orf47, DOK3, FGF11, MEST, and PFKFB4 were significantly correlated with the activation of fibroblast positively (Figure 3) Because the expression levels of these genes are also elevated in keloids compared with normal scars, these genes may contribute to the proliferative phase in the early formation of keloids by promoting fibroblast activation. The gene discussed is PFKFB4; the disease is keloid.