MAP1LC3B and obstructive sleep apnea syndrome: As such, autophagy-related marker proteins were detected in these patient samples to gauge autophagic flux, revealing that OSA patients exhibited an increased hepatic LC3B to LC3A ratio and lower levels of p62 as compared to non-OSA patient samples (Figures 1B,C), consistent with high levels of hepatic autophagic flux in individuals suffering from OSA.