The underlying cause of the low proportion of Tregs in SLE is not clear, but it may be related to the cytokine environment, promoting a decreased Treg proportion; but there are also other interesting possibilities in relation to both atherosclerosis and SLE including OxLDL and so‐called natural antibodies, especially anti‐PC but also a plasma protein, annexin A5. The gene discussed is ANXA5; the disease is atherosclerosis.