Strikingly, compared with mice incubated with NS, mice in two genotypes treated with L. reuteri displayed obviously mitigated AP, including decreased histopathological score, serum amylase and lipase and level of pro-inflammatory cytokines (serum TNF-α, IL-6 and IL-1β) (Figure 6e-g). This evidence concerns the gene IL1B and alkaline phosphatase measurement.