Using diagnosis (AD versus controls; AD as positive events, and controls as negative events) as the dependent variable and the 12 circRNAs, age, sex, years of education, and APOE ε4 status as covariates, we established a binary logistic regression model to assess the performance of the aforementioned 12 circRNAs in distinguishing patients with AD from controls. This evidence concerns the gene APOE and Alzheimer disease.