MAPKAPK2 and Neonatal onset: Of interest, another MK2 inhibitor, ATI-450 (formerly CDD-450), showed inhibition of LPS-induced TNF for up to 4 weeks after dosing in a mouse model of neonatal-onset multisystem inflammatory disease (NOMID), whereas the global p38α inhibitor CDD-111 (also known as SD-0006) did not [49].