TNF and neutropenia: The lack of neutropenia following 2 weeks of dosing with CC-99677 is encouraging given the mechanism of CC-99677 in inhibiting GM-CSF, TNF, and IL-6 production, as GM-CSF is important in stem cell differentiation into neutrophils, and both TNF and IL-6 blockade are associated with dose-dependent neutropenia [47, 48].