T-3861174, a prolyl-tRNA synthetase (PRS) inhibitor, was reported to promote apoptosis in melanoma SK-MEL-2 cells by activating the GCN2-ATF4 pathway, and the apoptosis-inducing activity of T-3861174 was eliminated when GCN2 was knocked down [55]. The gene discussed is WNK3; the disease is melanoma.