Six distinct immune infiltration types were identified in human tumors, including C1 (wound healing), C2 (IFN-γ dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGF-β dominant), although the C5 and C6 immune subtypes were excluded due to their absence in CM patients. This evidence concerns the gene TGFB1 and cutaneous mastocytosis.