In COVID-19 patients, cellular components released into the blood (e.g., viral proteins, RNA, and debris in general) as a result of a cytolytic event could be harmful not only by directly increasing the risk of coagulopathy and stroke [228] but also by indirectly increasing BBB permeability, allowing the virus to infect astrocytes, which do express high levels of ACE2 and TMPRSS2 [26]. This evidence concerns the gene ACE2 and COVID-19.