In addition to its anticoagulant properties, heparin is known to have anti-inflammatory effects on endothelial cells, leading to reduced translocation of nuclear factor kappa B (NF-κB) transcription factor and production of inflammatory markers, such as IL-1β, IL-6, E-selectin, and intercellular adhesion molecule (ICAM)-1 [246], which could positively impact the inflammation associated with COVID-19. This evidence concerns the gene IL1B and COVID-19.