In addition, KEGG pathway analysis revealed that Staphylococcus aureus infection, leishmaniasis, osteoclast differentiation, tuberculosis, phagosome and systemic lupus erythematosus, synaptic vesicle cycle, epithelial cell signalling in Helicobacter pylori infection, GABAergic synapse and neuroactive ligand−receptor interaction signals were involved in HK2-associated pathways (Fig. 6L-M). Here, HK2 is linked to systemic lupus erythematosus.