In addition, KEGG pathway analysis revealed that Staphylococcus aureus infection, leishmaniasis, osteoclast differentiation, tuberculosis, phagosome and systemic lupus erythematosus, synaptic vesicle cycle, epithelial cell signalling in Helicobacter pylori infection, GABAergic synapse and neuroactive ligand−receptor interaction signals were involved in HK2-associated pathways (Fig. 6L-M). The gene discussed is HK2; the disease is leishmaniasis.