In addition, univariate Cox regression analyses indicated significant correlations between the expression of these hub genes (ITGB2, CD53, C3AR1, CYBB, ITGAM, SYP, CPLX1, GABRG2, SLC6A1 and SCRT1) and the prognosis of glioma (Supplementary Fig. S6A-B). This evidence concerns the gene CD53 and central nervous system cancer.