Moreover, further multivariate Cox regression analysis revealed that the expression of CYBB (P = 0.00087), CD53 (P = 0.04883), SCRT1 (P = 0.00071) and SYP (P = 0.02491) can be independent factors of the prognosis of gliomas (Supplementary Fig. S6C-D) and predict the survival of glioma patients (Supplementary Fig. S6E-F). Here, CD53 is linked to central nervous system cancer.