In addition, univariate Cox regression analyses indicated significant correlations between the expression of these hub genes (ITGB2, CD53, C3AR1, CYBB, ITGAM, SYP, CPLX1, GABRG2, SLC6A1 and SCRT1) and the prognosis of glioma (Supplementary Fig. S6A-B). Here, CPLX1 is linked to central nervous system cancer.