Our results indicated that HK2 expression was positively correlated with histological manifestations (P = 5.9e-23), malignancy (P = 7.6e-19), IDH mutation (P = 2.6e-14), 1p/19q co-deletion (P = 2e-32), IDH mutation & 1p/19q co-deletion (P = 1.7e-26), and 1p/19q co-deletion in different grades (P = 0.012, P = 1.5e-18, and P = 6.6e-07, respectively) in glioma patients (Supplementary Fig. S2A-F). This evidence concerns the gene IDH2 and central nervous system cancer.